CURIOX APPLICATIONS
FLOW CYTOMETRY
AUTOMATE FLOW CYTOMETRY SAMPLE PREPARATION WITH LAMINAR WASH TECHNOLOGY
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- Applications _ Flow Cytometry
Overview
Upgrade how you process cells to get reliably consistent data
Laminar Wash technology is for scientists who believe that quantitative flow cytometry is critical to cell therapy, immuno-oncology, and other fields where cell analysis is important.
Flow cytometry depends on data consistency and reproducibility to yield biologically relevant information. Yet traditional sample prep methods often fail to deliver on these key criteria. How can we address this challenge?
By moving away from centrifugation, the traditional way of processing your cells, and automating your flow cytometry workflow, from sample preparation to data analysis using laminar washing. This process allows for standardization of sample preparation methods for various cell analysis applications.
Laminar Wash technology significantly improves debris removal, increasing the retention and viability of rare cell populations. The distinct resolution and identification of target and rare cellular populations supports the gamut of therapeutic development, from biomarker identification and discovery, to predicting cellular expansion success during manufacturing.
By eliminating centrifugation and supernatant removal steps
(e.g., aspirating and flicking), Laminar Wash reduces sample handling and hands-on time, freeing your lab to take on more challenging endeavors.
If you’re interested in obtaining the most reproducible data among users and locations, then Laminar Wash technology is for you.
“Due to its underlying principle, the Laminar Wash (technology) means less mechanical stress on cells and less cell loss from a sample that is compared to conventional centrifugation steps.”
Traditional centrifugation
VS
Laminar flow technology
Comparison of an immuno-staining workflow for the preparation of a single cell suspension for flow cytometry analysis. Laminar Wash technology is equally effective in washing but without the use of a centrifuge.
Benefits
Laminar wash is an affordable and simple solution to automate sample prep for flow cytometry:
- Improved resolution of cell populations, including rare cell types
- Reduced debris and cellular aggregation
- Significant time saving of 70~90 % in processing cells, allowing scientists to spend more time on analysis and science
- Keeping cells un-stressed in their native state, improving viability
- Practical integration with cell analysis workflows, particularly in combination with automated data analysis
Scientific Data
Laminar wash adds value to research and development
Improved enumeration of γδ T Cells with Laminar Wash™ in whole blood assay
Laminar Wash Improves Gating of Live Cells
- Better retention of live cells
- Higher stain index of VD2 marker
- Higher enumeration of rare gamma/delta T cells
Improved Operator Consistency by Automating Only the Wash Step
Laminar Wash Reduces Operator Variability.
After adopting the Laminar Wash technology users experienced low CVs in populations between operators and between experimental days.
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